Cortactin (CTTN) Rabbit Monoclonal Antibody [Clone ID: R07-2C5]

Specifications

Product Data
Clone Name	R07-2C5
Applications	IF, IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20-1/100 ICC/IF: 1/200 IP: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Cortactin
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 62 kDa; Observed MW: 80-85 kDa
Gene Name	cortactin
Database Link	Entrez Gene 2017 Human UniProt ID Q14247
Background	Swiss-Prot Acc.Q14247.Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones . Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density . Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover . In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits . Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).
Synonyms	1110020L01Rik; Amplaxin; cortactin; EMS1; FLJ34459
Reference Data

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