Emerin (EMD) Rabbit Monoclonal Antibody [Clone ID: R02-5J7]

Specifications

Product Data
Clone Name	R02-5J7
Applications	IF, IHC, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20 ICC/IF: 1/50
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Emerin
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 29 kDa; Observed MW: 35 kDa
Gene Name	emerin
Database Link	Entrez Gene 2010 Human UniProt ID P50402
Background	Swiss-Prot Acc.P50402.Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Synonyms	EDMD; emerin; LEMD5; STA
Reference Data

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