G3BP (G3BP1) Rabbit Monoclonal Antibody [Clone ID: R06-5D2]

Specifications

Product Data
Clone Name	R06-5D2
Applications	IF, IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20 ICC/IF: 1/20 IP: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human G3BP
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 52 kDa; Observed MW: 68 kDa
Gene Name	G3BP stress granule assembly factor 1
Database Link	Entrez Gene 10146 Human UniProt ID Q13283
Background	Swiss-Prot Acc.Q13283.ATP- and magnesium-dependent helicase (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510). Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). May be a regulated effector of stress granule assembly (PubMed:12642610, PubMed:20180778).
Synonyms	G3BP; G3BP-1; HDH-VIII; MGC111040
Reference Data

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