Aspartate Aminotransferase (GOT1) Rabbit Monoclonal Antibody [Clone ID: R05-6C1]

Specifications

Product Data
Clone Name	R05-6C1
Applications	IF, IHC, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20-1/100 ICC/IF: 1/100-1/100
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Aspartate Aminotransferase
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 46 kDa; Observed MW: 46 kDa
Gene Name	glutamic-oxaloacetic transaminase 1
Database Link	Entrez Gene 2805 Human UniProt ID P17174
Background	Swiss-Prot Acc.P17174.Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Synonyms	GIG18
Reference Data

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