HDAC8 Rabbit Monoclonal Antibody [Clone ID: R03-4G9]

Specifications

Product Data
Clone Name	R03-4G9
Applications	IP, WB
Recommend Dilution	WB: 1/2000-1/10000 IP: 1/20
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human HDAC8
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 42 kDa; Observed MW: 42 kDa
Gene Name	histone deacetylase 8
Database Link	Entrez Gene 55869 Human UniProt ID Q9BY41
Background	Swiss-Prot Acc.Q9BY41.Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
Synonyms	CDA07; HD8; HDACL1; RPD3
Reference Data

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