IL18 Rabbit Monoclonal Antibody [Clone ID: R02-8B2]

Specifications

Product Data
Clone Name	R02-8B2
Applications	IHC, WB
Recommend Dilution	WB: 1/1000 IHC: 1/200
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human IL18
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 22 kDa; Observed MW: 17 kDa
Gene Name	interleukin 18
Database Link	Entrez Gene 3606 Human UniProt ID Q14116
Background	Swiss-Prot Acc.Q14116.A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).
Synonyms	Iboctadekin; IGIF; IL-1g; IL-18; IL1F4; interleukin-18; MGC12320
Reference Data

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