Myelin Basic Protein (MBP) Rabbit Monoclonal Antibody [Clone ID: R08-9K4]

Specifications

Product Data
Clone Name	R08-9K4
Applications	WB
Recommend Dilution	WB: 1/1000
Reactivity	Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Myelin Basic Protein
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 33 kDa; Observed MW: 18 kDa
Gene Name	myelin basic protein
Database Link	UniProt ID P02686
Background	Swiss-Prot Acc.P02686.The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Synonyms	Golli-mbp; MGC99675; OTTHUMP00000174383
Reference Data

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