Cyclophilin F (PPIF) Rabbit Monoclonal Antibody [Clone ID: R02-6I9]
CAT#: TA385023
Cyclophilin F Rabbit monoclonal Antibody
Size: 20 ul
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CNY 1,999.00
CNY 3,280.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Clone Name | R02-6I9 |
Applications | IHC, WB |
Recommend Dilution | WB: 1/1000 IHC: 1/500 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Monoclonal |
Immunogen | A synthetic peptide of human Cyclophilin F |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Predicted Protein Size | Calculated MW: 22 kDa; Observed MW: 18 kDa |
Gene Name | peptidylprolyl isomerase F |
Database Link | |
Background | Swiss-Prot Acc.P30405.PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. |
Synonyms | Cyp-D; CYP3; FLJ90798; hCyP3; MGC117207; PPIase; rotamase |
Reference Data |
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