PSMB8 Mouse Monoclonal Antibody [Clone ID: 3G3-C1-E2]

Specifications

Product Data
Clone Name	3G3-C1-E2
Applications	IF, IHC, WB
Recommend Dilution	WB: 1/500-1/2000 IHC: 1/200-1/1000 ICC: 1/200-1/1000
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human PSMB8 expressed in E. Coli.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration	lot specific
Purification	Ascitic Fluid
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	30kDa
Gene Name	proteasome subunit beta 8
Database Link	Entrez Gene 5696 Human UniProt ID P28062
Background	Swiss-Prot Acc.P28062.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.
Synonyms	beta5i; D6S216; D6S216E; LMP7; MGC1491; PSMB5i; RING10; Y2
Reference Data

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