PSMB8 Rabbit Monoclonal Antibody [Clone ID: R09-1H1]

Specifications

Product Data
Clone Name	R09-1H1
Applications	IF, IP, WB
Recommend Dilution	WB: 1/2000-1/10000 ICC/IF: 1/20 IP: 1/20
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human LMP7
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 30 kDa; Observed MW: 23 kDa
Gene Name	proteasome subunit beta 8
Database Link	Entrez Gene 5696 Human UniProt ID P28062
Background	Swiss-Prot Acc.P28062.The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.
Synonyms	beta5i; D6S216; D6S216E; LMP7; MGC1491; PSMB5i; RING10; Y2
Reference Data

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