Prostaglandin D Synthase (PTGDS) Rabbit Monoclonal Antibody [Clone ID: R06-1C5]

Specifications

Product Data
Clone Name	R06-1C5
Applications	IF, IHC, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20 ICC/IF: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Prostaglandin D Synthase
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 21 kDa; Observed MW: 26 kDa
Gene Name	prostaglandin D2 synthase
Database Link	Entrez Gene 5730 Human UniProt ID P41222
Background	Swiss-Prot Acc.P41222.Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-Tis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
Synonyms	Cerebrin-28; L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2
Reference Data

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