RAD51 Rabbit Monoclonal Antibody [Clone ID: R06-5G2]

Specifications

Product Data
Clone Name	R06-5G2
Applications	IF, IP, WB
Recommend Dilution	WB: 1/2000-1/10000 ICC/IF: 1/200-1/100 IP: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Rad51
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 37 kDa; Observed MW: 37 kDa
Gene Name	RAD51 recombinase
Database Link	Entrez Gene 5888 Human UniProt ID Q06609
Background	Swiss-Prot Acc.Q06609.Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).
Synonyms	BRCC5; HRAD51; HsRad51; HsT16930; RAD51A; RAD51D; RAD51L3; RECA
Reference Data

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