Rb2 p130 (RBL2) Rabbit Monoclonal Antibody [Clone ID: R02-5D6]

Specifications

Product Data
Clone Name	R02-5D6
Applications	IF, IHC, WB
Recommend Dilution	WB: 1/2000-1/10000 IHC: 1/20-1/100 ICC/IF: 1/20-1/100
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic phosphopeptide corresponding to residues surrounding Ser952 of human Rb2 p130 (Phosphorylated)
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 128 kDa; Observed MW: 130 kDa
Gene Name	RB transcriptional corepressor like 2
Database Link	Entrez Gene 5934 Human UniProt ID Q08999
Background	Swiss-Prot Acc.Q08999.Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Synonyms	FLJ26459; p130; PRB2; Rb2; RBR-2
Reference Data

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