S100 beta (S100B) Rabbit Monoclonal Antibody [Clone ID: R01-1F9]

Specifications

Product Data
Clone Name	R01-1F9
Applications	IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/50-1/200 IP: 1/20
Reactivity	Human, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human S100 beta
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 11 kDa; Observed MW: 11 kDa
Gene Name	S100 calcium binding protein B
Database Link	Entrez Gene 6285 Human UniProt ID P04271
Background	Swiss-Prot Acc.P04271.Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Synonyms	NEF; OTTHUMP00000174958; S100; S100beta
Reference Data

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