PAI1 (SERPINE1) Rabbit Monoclonal Antibody [Clone ID: R07-2C3]

Specifications

Product Data
Clone Name	R07-2C3
Applications	WB
Recommend Dilution	WB: 1/1000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of mouse PAI1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 45 kDa; Observed MW: 45 kDa
Gene Name	serpin family E member 1
Database Link	Entrez Gene 5054 Human UniProt ID P05121
Background	Swiss-Prot Acc.P05121.Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung . Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
Synonyms	PAI; PAI-1; PAI1; PLANH1
Reference Data

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