TCF7L2 Rabbit Monoclonal Antibody [Clone ID: R09-1D1]
CAT#: TA385383
Transcription Factor 7 Like 2 Rabbit monoclonal Antibody
Size: 20 ul
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CNY 1,999.00
CNY 3,280.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Clone Name | R09-1D1 |
Applications | IHC, IP, WB |
Recommend Dilution | WB: 1/1000 IHC: 1/50 IP: 1/20 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Immunogen | A synthetic peptide of human TCF-4 |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Predicted Protein Size | Calculated MW: 68 kDa; Observed MW: 68 kDa |
Gene Name | transcription factor 7 like 2 |
Database Link | |
Background | Swiss-Prot Acc.Q9NQB0.Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine. |
Synonyms | hTCF-4; TCF-4; TCF4 |
Reference Data |
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