VDAC1 Rabbit Monoclonal Antibody [Clone ID: R05-7F2]

Specifications

Product Data
Clone Name	R05-7F2
Applications	IHC, WB
Recommend Dilution	WB: 1/2000 IHC: 1/20-1/500
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human VDAC1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 31 kDa; Observed MW: 31 kDa
Gene Name	voltage dependent anion channel 1
Database Link	Entrez Gene 7416 Human UniProt ID P21796
Background	Swiss-Prot Acc.P21796.Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).
Synonyms	hVDAC1; MGC111064; OTTHUMP00000159381; OTTHUMP00000165946; PORIN; PORIN-31-HL; VDAC; VDAC-1
Reference Data

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