IL2 Receptor alpha (IL2RA) Mouse Monoclonal Antibody [Clone ID: Basiliximab]
CAT#: TA385812
Recombinant Anti-IL-2R alpha (CD25) (Clone Basiliximab)
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CNY 7,170.00
货期*
6周
规格
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Specifications
Product Data | |
Clone Name | Basiliximab |
Applications | Bl, FC, IF, IHC, WB |
Reactivity | Human, Monkey |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Basiliximab was prepared by immunizing BALB/c mice with CTC 16 cells. |
Specificity | Basiliximab recognises the human IL-2R and binds to the epitope (116)ERIYHFV(122) within the extracellular domain of the CD25 subunit – binding is abolished when 2 or more residues within the epitope are mutated. This epitope overlaps with the interaction site of CD25 and IL-2. CD25 is found in the high-affinity IL-2R (αβγc) – T cells only express CD25 upon activation. IL-2 binding to IL-2R on T cells modulates proliferation and differentiation. Basiliximab is derived from the murine anti-Tac antibody. For the clinically used format, the variable regions from this antibody were grafted onto the sequence of the human IgG1κ constant regions. Basiliximab binding to CD25 competitively blocks the interaction of IL-2R with its ligand IL-2 on the surface of T cells. Blocking this interaction prevents T cell replication and T cell-mediated B cell activation. Basiliximab binding suppresses the immune system inhibits the pathway activating the cellular immune response to allograft rejection. IL-2 signalling suppression can additionally prevent acute graft-versus-host disease, autoimmune disorders and malignancies such as T cell leukemias (Binder et al, 2007). Basiliximab has also been used in FC, IF, IHC and WB studies, which enables the detection of CD25. |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles. |
Gene Name | interleukin 2 receptor subunit alpha |
Database Link | |
Synonyms | CD25; IDDM10; IL-2-RA; IL2-RA; IL2R; p55; TCGFR |
Note | NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This is a chimeric antibody created for improved compatibility with existing reagents, assays and techniques. |
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