Integrin alpha 5 (ITGA5) Rabbit Monoclonal Antibody [Clone ID: M200 (Volociximab)]
CAT#: TA385969
Recombinant Anti-alpha 5 beta 1 Integrin (Clone M200 (Volociximab))
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CNY 7,170.00
货期*
6周
规格
经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Clone Name | M200 (Volociximab) |
Applications | Bl, ELISA, FC, IF, IHC |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Immunogen | Heterodimeric α5β1Fc fusion protein |
Specificity | The antibody binds to human α5β1 integrin with a Kd of 0.367 nM (determined by Biacore), an EC50 of 0.2 nM and an IC50 of 2.3 nM. The antibody binds specifically to α5β1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The α5β1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec. |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles. |
Gene Name | integrin subunit alpha 5 |
Database Link | |
Synonyms | CD49e; FNRA; VLA-5; VLA5A |
Note | NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques. |
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