Vsir Rabbit Monoclonal Antibody [Clone ID: MH5A]
CNY 6,881.00
货期*
6周
规格
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Specifications
Product Data | |
Clone Name | MH5A |
Applications | Bl, ELISA, IHC |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Monoclonal |
Immunogen | The antibody was generated by immunising Armenian hamsters with mPD-1HIg. |
Specificity | This antibody specifically binds PD-1H. The antibody has been labelled with biotin and used to stain formalin-fixed tissues from wild-type C57BL/6 mice at 6 weeks of age. This showed specific staining for PD-1H in the T cell zone and marginal zone. The antibody stains P815 cells transfected with full-length PD-1H plasmid, but not control plasmid. Antibody specificity has been confirmed by ELISA. A single 200-μg dose of MH5A prevented aGVHD in mouse models, caused a reduction in accumulation and expansion of CD8+ and CD4+ T cells in spleens and livers and greatly reduced numbers of inflitrating T cells in all aGVHD target tissues examined. Few mAbs targeting a single cosignalling molecule have such a potent preventative effect (Flies D et al, 2011). |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles. |
Gene Name | V-set immunoregulatory receptor |
Database Link | |
Note | This chimeric rabbit antibody was made using the variable domain sequences of the original Hamster IgG format, for improved compatibility with existing reagents, assays and techniques. |
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