CCR5 Rabbit Monoclonal Antibody [Clone ID: T21/8]

Specifications

Product Data
Clone Name	T21/8
Applications	ELISA, FC, IF, IP, WB
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	This antibody was raised by immunizing mice with intact RBL-CCR5 cells.
Specificity	T21/8 antibody binds with high affinity to a CCR5 N-terminal epitope. CCR5 is a receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES. T21/8 antibody is recommedned for the detection and analysis of CCR5 via various methods. For instance, one group used this antibody to detect intracellular localization of CCR5 in RBL-CCR5 cells via immunofluorescence staining (Pollok-Kopp et al., 2003). Another group investigated ligand-mediated down-modulation of CCR5 via flow cytometry, utilizing T21/8 antibody (Fox et al., 2015). With other anti-CCR5 antibodies which react with CCR5 phosphorylated on different serine residues (Ab01578; Ab01579), it can be used to study dynamic regulation of CCR5 and phosphorylation mechanisms.
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	C-C motif chemokine receptor 5 (gene/pseudogene)
Database Link	Entrez Gene 1234 Human UniProt ID P51681
Synonyms	CC-CKR-5; CCCKR5; CCR-5; CD195; chemr13; CKR-5; CKR5; CMKBR5; FLJ78003; IDDM22; OTTHUMP00000209784
Note	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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