alpha Synuclein (SNCA) Mouse Monoclonal Antibody [Clone ID: 2A7]

Specifications

Product Data
Clone Name	2A7
Applications	ICC, IHC, WB
Recommend Dilution	WB: 1:1000 WB Brain: 1:1000 ICC: 1:1000
Reactivity	Bovine, Human, Mouse, Pig, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human alpha synuclein expressed in E. Coli.
Specificity	Specific for the endogenous levels of the ~15 kDa alpha synuclein protein.
Formulation	PBS + 50% glycerol and 5 mm NaN3
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Predicted Protein Size	15
Gene Name	synuclein alpha
Database Link	Entrez Gene 6622 Human UniProt ID P37840
Background	Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes (ChartierHarlin MC et al., 2004 and Singleton, AB et al., 2005). Alpha-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS).
Synonyms	alpha-synuclein; MGC110988; NACP; OTTHUMP00000161559; OTTHUMP00000161561; PARK1; PARK4; PD1
Note	Protein G purified.
Reference Data

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