Calbindin (CALB1) Mouse Monoclonal Antibody [Clone ID: 5A9]

Specifications

Product Data
Clone Name	5A9
Applications	IHC, WB
Recommend Dilution	WB: 1:2000 WB Brain: 1:2000
Reactivity	Bovine, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant full length human calbindin purified from E. coli.
Specificity	Specific for endogenous levels of the ~28 kDa calbindin protein.
Formulation	PBS + 50% glycerol and 5 mM NaN3
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Predicted Protein Size	28
Gene Name	calbindin 1
Database Link	Entrez Gene 793 Human UniProt ID P05937
Background	Calbindin (aka. calbindin D28k) is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. It is predominantly expressed in certain types of neurons, particularly in dendrites and perikarya of the cerebellum and is thought to buffer entry of calcium upon stimulation of glutamate receptors (Andressen et al., 1993). Calbindin has recently been shown to play a critical role in mitochondrial dysfunction and loss of synaptic proteins in vivo in an Alzheimer’s disease mouse model (Kook et al., 2014).
Synonyms	CAB27; CALB; D-28K
Note	Protein G purified culture supernatant.
Reference Data

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