Phospho-CBL (pTyr700) Mouse Antibody [Clone ID: M161]
CAT#: TA389077
Anti-c-Cbl (Tyr-700), Phosphospecific Antibody
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CNY 4,069.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | M161 |
Applications | WB |
Recommend Dilution | WB: 1:1000 |
Reactivity | Human, Rat, Mouse |
Host | Mouse |
Immunogen | Clone (M161) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding tyrosine 700 in human c-Cbl. This sequence is highly conserved in rat and mouse c-Cbl. |
Specificity | The antibody detects a 120 kDa* protein in human Jurkat cells treated with pervanadate, but not in control cells. |
Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
Concentration | lot specific |
Purification | Protein A Purified |
Conjugation | Unconjugated |
Storage Condition | Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
Predicted Protein Size | 120 |
Database Link | |
Background | c-Cbl proto-oncogene is a ubiquitously expressed cytoplasmic adaptor protein that is especially predominant in hematopoietic cells. c-Cbl possesses a highly conserved amino-terminal phosphotyrosine binding domain and a C3HC4 RING finger motif. c-Cbl is rapidly tyrosine phosphorylated in response to stimulation of a variety of cell-surface receptors and becomes associated with a number of intracellular signaling molecules such as protein tyrosine kinases, phosphatidylinositol 3 kinase (PI3K), Crk and 14-3-3 proteins. In human cancer tissues, c-Cbl is frequently tyrosine phosphorylated in a tumor-specific manner. Src-family kinases primarily phosphorylate c-Cbl at Tyr-700, Tyr-731, and Tyr-774. These sites of phosphorylation provide docking sites for downstream signaling components, such as Grb-2, PI3K, and Fyn. |
Note | Protein G purified tissue culture supernatant. |
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