PP2A-alpha (PPP2CA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000~1:2000
Reactivity	Rat, Mouse, Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human PP2A-α.
Specificity	PP2A-α polyclonal antibody detects endogenous levels of PP2A-α protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 35 kDa
Gene Name	protein phosphatase 2 catalytic subunit alpha
Database Link	Entrez Gene 5515 Human UniProt ID P67775
Background	PP2A is the major phosphatase for microtubule-associated proteins (MAPs).PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity).Can dephosphorylate SV40 large T antigen and p53/TP53.Activates RAF1 by dephosphorylating it at 'Ser-259'.Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC.Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3.
Synonyms	PP2A-alpha; Replication protein C; RP-C; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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