alpha smooth muscle Actin (ACTA2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000~1:2000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human α-SMA.
Specificity	α-SMA polyclonal antibody detects endogenous levels of α-SMA protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 45 kDa
Gene Name	actin, alpha 2, smooth muscle, aorta
Database Link	Entrez Gene 59 Human UniProt ID P62736
Background	Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
Synonyms	a-SMA; AAT6; ACTA2; Actin, aortic smooth muscle; ACTSA; Alpha-actin-2; alpha-SMA; aSMA; Cell growth-inhibiting gene 46 protein; MYMY5; SMA-alpha
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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