GRK2 Rabbit Polyclonal Antibody

CAT#: TA392740S

GRK 2 (D635) polyclonal antibody

Size: 25 ul 100 ul



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CNY 800.00


货期*
2周

规格
    • 25 ul

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经常一起买 (1)
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Specifications

Product Data
Applications WB
Recommend Dilution WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:10~1:100
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to amino acids 600-650 of Human GRK2.
Specificity GRK 2 (D635) polyclonal antibody detects endogenous levels of GRK 2 protein.
Formulation Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration 1mg/ml
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size ~ 80 kDa
Gene Name G protein-coupled receptor kinase 2
Background Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second messenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of β-adrenergic receptor kinase, GRK 2 (βARK, βARK1) and GRK 3 (βARK2); IT-11 (GRK 4); GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Synonyms ADRBK1; ARK-β1; ARK β1; ARKβ1; BARK; BARK1; Beta-adrenergic receptor kinase 1; Beta-ARK-1; G-protein coupled receptor kinase 2; GRK2; β-ARK-1; β-ARK1
Note For research use only, not for use in diagnostic procedure.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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