NFIL3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 32-86 of Human E4BP4.
Specificity	E4BP4 (E65) polyclonal antibody detects endogenous levels of E4BP4protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 60 kDa
Gene Name	nuclear factor, interleukin 3 regulated
Database Link	Entrez Gene 4783 Human UniProt ID Q16649
Background	E4BP4, also known as NFIL3, functions as a transcriptional repressor and is a member of the basic leucine zipper (bZIP) transcription factor family. E4BP4 binds with high specificity to the E4 ATF, which is a DNA sequence traditionally targeted by the ATF/CREB family of transcription factors. A 65 amino acid segment located in the carboxy-terminus of E4BP4 interacts specifically with the TBP binding protein Dr1. In the suprachiasmatic nucleus, circadian center and liver, E4BP4 competes with PAR proteins for DNA binding via a reciprocating mechanism. The phase expression of E4BP4 correlates with the circadian cycle and represses transcription of genes otherwise activated by PAR transcription regulators. E4BP4 also plays an important role in an IL-3-mediated signaling pathway that is responsible for the survival of B cell progenitors. The gene encoding human E4BP4 maps to chromosome 9q22.
Synonyms	E4 promoter-binding protein 4; E4 promoter binding protein 4; E4BP 4; E4BP4; E4BP4 protein; IL3BP 1; IL3BP1; Interleukin-3 promoter transcriptional activator; Interleukin-3-binding protein 1; Interleukin 3 binding protein 1; Interleukin 3 promoter transcriptional activator; NFIL 3; NFIL3; NFIL 3A; NFIL3A; Nuclear factor interleukin-3-regulated protein; Nuclear factor interleukin 3 regulated; Transcriptional activator NF-IL3A; Transcriptional activator NF IL3A
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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