PRP19 (PRPF19) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding Human PRPF19.
Specificity	PRPF19 polyclonal antibody detects endogenous levels of PRPF19 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 55 kDa
Gene Name	pre-mRNA processing factor 19
Database Link	Entrez Gene 27339 Human UniProt ID Q9UMS4
Background	The spliceosome, the 0gigantic molecular machine that performs pre-mRNA splicing in eukaryotes, contains over 200 different proteins and five RNA molecules (U1, U2, U4, U5 and U6). Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The PRP19-associated complex is required for stable association of U5 and U6 with the spliceosome after U4 is released. Changes within the spliceosome upon binding of the PRP19-associated complex include remodeling of the U6/5‘ splice site interaction and destabilization of Lsm proteins to allow further interaction of U6 with the intron sequence.
Synonyms	hPso4; NMP200; Nuclear matrix protein 200; Pre-mRNA-processing factor 19; PRP19; PRP19/PSO4 homolog; PRPF19I; RING-type E3 ubiquitin transferase PRP19; Senescence evasion factor; SNEV
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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