SAR1B Rabbit Polyclonal Antibody
CAT#: TA392844
Sar1b (F151) polyclonal antibody
Size: 25 ul
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1:500~1:1000 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 121-181 of Human Sar1b. |
Specificity | Sar1b (F151) pAb detects endogenous levels of Sar1b protein. |
Formulation | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Concentration | 1mg/ml |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Predicted Protein Size | ~ 22 kDa |
Gene Name | secretion associated Ras related GTPase 1B |
Database Link | |
Background | There are a number of components involved in the secretory pathway of cells. Vesicular traffic within the early secretory pathway is mediated by COPI- and COPII-coated vesicles. The COPII vesicle coat protein promotes the formation of endoplasmic reticulum (ER) derived transport vesicles that carry secretory proteins to the Golgi complex. The SAR1 gene encodes two isoforms, Sar1a and Sar1B, in mammalian cells. These proteins are low-molecular-weight GTPases, which are essential for the formation of transport vesicles from the ER. Mutations in the SAR1 gene result in Anderson’s disease (and/or chylomicron retention disease CMRD), a rare, autosomal recessive lipid malabsorption disorder characterized by chronic diarrhea, failure to thrive and hypocholesterolemia in childhood. |
Synonyms | GTBPB; GTP-binding protein B; GTP-binding protein SAR1b; SAR1B; SARA2; SARB |
Note | For research use only, not for use in diagnostic procedure. |
Reference Data |
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