Cytokeratin 18 (KRT18) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IHC: 1:50~1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human Cytokeratin 18 around the phosphorylation site of Serine 33.
Specificity	p-Cytokeratin 18 (S33) polyclonal antibody detects endogenous levels of Cytokeratin 18 protein only when phosphorylated at Ser33.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 46 kDa
Gene Name	keratin 18
Database Link	Entrez Gene 3875 Human UniProt ID P05783
Background	Cytokeratin 18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Involved in the uptake of thrombin-antithrombin complexes by hepatic cells By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Synonyms	Cell proliferation-inducing gene 46 protein; CK-18; CK 18; CK18; CYK18; Cytokeratin-18; Keratin, type I cytoskeletal 18; Keratin-18; Keratin 18; Keratin18; KRT 18; KRT18; PIG46; Short name=CK-18; Short name=K18
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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