WNK1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IHC: 1:50~1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human WNK1 around the phosphorylation site of Threonine 60.
Specificity	p-WNK1 (T60) polyclonal antibody detects endogenous levels of WNK1 protein only when phosphorylated at Thr60.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 251 kDa
Gene Name	WNK lysine deficient protein kinase 1
Database Link	Entrez Gene 65125 Human UniProt ID Q9H4A3
Background	WNK1 (WNK lysine deficient protein kinase 1), also known as KDP (kinase deficient protein), PSK, erythrocyte 65 kDa protein (p65), HSN2, HSAN2 or PRKWNK1, is a 2,382 amino acid cytoplasmic protein that participates in cell signaling, proliferation and survival, and regulates electrolyte homeostasis. WNK1 belongs to the Ser/Thr protein kinase family of the protein kinase superfamily, and contains one protein kinase domain. Existing as five alternatively spliced isoforms, WNK1 is widely expressed but is found at highest levels in skeletal muscke, heart, testis and kidney. The gene that encodes WNK1 maps to human chromosome 12p13.33, and when defective, is the cause of an an autosomal dominant disease known as pseudohypoaldosteronism type II (PHAII), as well as a hereditary sensory and autonomic neuropathy designated hereditary sensory and autonomic neuropathy type 2A (HSAN2A).
Synonyms	Erythrocyte 65 kDa protein; HSN2; hWNK1; KDP; KIAA0344; Kinase deficient protein; PRKWNK1; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; Serine/threonine-protein kinase WNK1; WNK
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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