Insulin Receptor (INSR) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IHC: 1:50~1:200
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human Insulin Receptor around the phosphorylation site of Tyrosine 1355.
Specificity	p-Insulin Receptor (Y1355) polyclonal antibody detects endogenous levels of Insulin Receptor protein only when phosphorylated at Tyr1355.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 156 kDa
Gene Name	insulin receptor
Database Link	Entrez Gene 3643 Human UniProt ID P06213
Background	The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular β subunit and an extracellular α subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin.
Synonyms	CD220; INSR; Insulin receptor; IR
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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