Tyrosine Hydroxylase (TH) Rabbit Polyclonal Antibody
CAT#: TA392937S
TH (phospho-S8) polyclonal antibody
Size: 100 ul
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1:500~1:1000 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide derived from human TH around the phosphorylation site of S8. |
Specificity | TH (phospho-S8) polyclonal antibody detects endogenous levels of TH protein only when phosphorylated at Ser8. |
Formulation | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Concentration | 1mg/ml |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Predicted Protein Size | ~ 58 kDa |
Gene Name | tyrosine hydroxylase |
Database Link | |
Background | The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson’s disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds |
Synonyms | TH; TYH; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase |
Note | For research use only, not for use in diagnostic procedure. |
Reference Data |
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