ZIP Kinase (DAPK3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human DAPK3 around the phosphorylation site of Thr265.
Specificity	DAPK3 (phospho-T265) polyclonal antibody detects endogenous levels of DAPK3 protein when phosphorylated at Thr265.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 52 kDa
Gene Name	death associated protein kinase 3
Database Link	Entrez Gene 1613 Human UniProt ID O43293
Background	Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certainserine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N terminal kinase domain and a C terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREBfamily. ZIP kinase has high sequence homology to DAP kinase (death associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues.
Synonyms	Dapk 3; Dapk3; DAP kinase 3; DAP like kinase; Death associated kinase 3; Death associated protein kinase 3; Dlk; ZIP; ZIP-kinase; ZIPK; ZIP kinase
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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