PKC delta (PRKCD) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IHC: 1:50~1:200
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human PKC δ around the phosphorylation site of Serine 645.
Specificity	p-PKC δ (S645) polyclonal antibody detects endogenous levels of PKC δ protein only when phosphorylated at Ser645.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 80 kDa
Gene Name	protein kinase C delta
Database Link	Entrez Gene 5580 Human UniProt ID Q05655
Background	Protein Kinase C delta (PKC delta) is a 78 kDa member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine, and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC delta is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of multiple cellular processes including cell cycle progression and apoptosis. Autophosphorylation of serine 664 (serine 662 in mouse and rat) contributes to PKC delta activity. Serum dependent phosphorylation of serine 664 is mediated by mTOR pathway, is protected from dephosphorylation by phosphorylated threonine 505 in the activation loop, and is implicated in prolactin signaling.
Synonyms	nPKC-delta; PKCδ; PRKCD; Protein kinase C delta type; SDK1; Sphingosine-dependent protein kinase-1; Tyrosine-protein kinase PRKCD
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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