GPC3 Rabbit Monoclonal Antibody [Clone ID: 15G1]
CAT#: TA399834
Anti-Glypican 3 [15G1], Rabbit IgG, kappa
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CNY 6,881.00
货期*
6周
规格
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Specifications
Product Data | |
Clone Name | 15G1 |
Applications | ELISA, FC, IHC |
Reactivity | Human, Monkey, Rat |
Modifications | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques. |
Host | Rabbit |
Clonality | Monoclonal |
Immunogen | The original antibody was generated by immunizing BALB/c mice with a recombinant human GPC3 extracellular domain (ECD, amino acids of 1-547) fused to a C-terminal Flag (RADYKDDDDK). |
Specificity | This antibody binds an epitope between amino acids 420 to 470 of the human glypican 3 (GPC3). This antibody cross reacts with cynomolgus monkey and rat GPC3. Glypican-3 is an oncofetal antigen that belongs to the glypican family of glycosyl-phosphatidylinositol-anchored heparin sulfate proteoglycans. It negatively regulates the hedgehog signaling pathway and positively regulates the canonical Wnt signaling pathway. Multiple studies have revealed that GPC-3 is overexpressed in hepatocellular carcinoma (HCC). This antibody can bind human glypican 3 expressed on the surface of 293S cells, HepG2 X1 cells and JHH7 cells in a flow cytometric assay. This antibody reacts with human rat and cynomolgus monkey GPC3 in a flow cytometric assay. The binding characterization of this antibody to huGPC3, cynoGPC3, and HepG2 cells was done using ELISA and immunohistochemistry. (US9926377). |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
Database Link | |
Synonyms | DGSX; Glypican-3; GPC-3; GPC3; GTR2-2; Intestinal protein OCI-5; MXR7; OCI5 |
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