MAPK8 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Dot, ICC/IF, WB
Recommend Dilution	WB,1:2000 - 1:20000 IF/ICC,1:50 - 1:200 DB,1:500 - 1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 200-300 of human JNK1 (NP_620637.1).
Formulation	Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	35kDa/44kDa/48kDa - Observed MW: 44kDa/54kDa
Database Link	UniProt ID P45983
Background	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
Synonyms	JNK; JNK-46; JNK1; JNK1A2; JNK3; JNK3A; JNK21B1/2; p54bSAPK; p493F12; PRKM8; PRKM10; SAPK1; SAPK1b; SAPK1c
Reference Data

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