Phospho-ATR Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB,1:1000 - 1:5000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic phosphorylated peptide around S428 of human ATR (NP_001175.2).
Formulation	Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	301kDa - Observed MW: 300kDa
Gene Name	ATR serine/threonine kinase
Database Link	Entrez Gene 545 Human UniProt ID Q13535
Background	The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Synonyms	FCTCS; FRP1; MEC1; SCKL; SCKL1
Reference Data

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