Fcgr1 Rat Monoclonal Antibody [Clone ID: AT152-9]

Specifications

Product Data
Clone Name	AT152-9
Applications	FC, IHC
Host	Rat
Clonality	Monoclonal
Immunogen	HEK293F cells expressing CD64 and gamma chain
Specificity	CD64
Formulation	TRIS buffered saline containing <0.1% Sodium Azide (NaN3) Label: FITC,Purified State: Purified IgG prepared by ion exchange chromatography from tissue culture supernatant Purified IgG - liquid
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	+4°C, -20°C if preferred
Gene Name	Fc receptor, IgG, high affinity I
Database Link	UniProt ID P26151
Background	Rat anti mouse CD64 antibody, clone AT152-9, recognizes mouse CD64 also known as FcRI. CD64 is a high affinity activatory receptor for IgG2a and a low affinity receptor for IgG2b and IgG3 type antibodies. The interaction between Fc receptors and antibodies play important roles in both the innate and adaptive immune responses.CD64, through binding of the Fc segment of IgG, mediates phagocytosis and plays a role in antibody-dependent cellular cytotoxicity and clearance of immune complexes. In addition, CD64 also functions as an antigen capture for presentation to T-cells and also mediates the release of cytokines and reactive oxygen intermediates including interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF) alpha. It is constitutively expressed on monocytes and macrophages, germinal centre dendritic cells and early myeloid lineage cells, but not lymphocytes. Expression on monocytes can be strongly upregulated by treatment with interferon (IFN) gamma or G-CSF, and can be induced on neutrophils and eosinophils by IFN gamma.
Synonyms	FcRI
Reference Data

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