Melanoma gp100 (PMEL) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI10E5]

Specifications

Product Data
Clone Name	OTI10E5
Applications	IF, IHC, WB
Recommend Dilution	WB 1:1000 IHC 1:50 IF 1:100 Flow 1:500
Reactivity	Human, Dog, Rat, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length protein expressed in 293T cell transfected with human SILV expression vector
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	70.3 kDa
Gene Name	premelanosome protein
Database Link	NP_008859 Entrez Gene 362818 RatEntrez Gene 481102 DogEntrez Gene 710921 MonkeyEntrez Gene 6490 Human UniProt ID P40967
Background	Could be a melanogenic enzyme. Could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity
Synonyms	D12S53E; gp100; ME20; ME20-M; ME20M; P1; P100; PMEL17; SI; SIL; SILV
Reference Data
Protein Families	Secreted Protein, Transmembrane

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