ERAB (HSD17B10) Mouse Monoclonal Antibody [Clone ID: OTI3B5]

Specifications

Product Data
Clone Name	OTI3B5
Applications	WB
Recommend Dilution	WB 1:2000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length protein expressed in 293T cell transfected with human HSD17B10 expression vector
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	26.9 kDa
Gene Name	hydroxysteroid 17-beta dehydrogenase 10
Database Link	NP_004484 Entrez Gene 15108 MouseEntrez Gene 63864 RatEntrez Gene 3028 Human UniProt ID Q99714
Background	This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Synonyms	17b-HSD10; ABAD; CAMR; DUPXp11.22; ERAB; HADH2; HCD2; MHBD; MRPP2; MRX17; MRX31; MRXS10; SCHAD
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Alzheimer's disease, Metabolic pathways, Valine, leucine and isoleucine degradation

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