TPMT Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI4C1]

Specifications

Product Data
Clone Name	OTI4C1
Applications	FC, IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:50, Flow 1:100
Reactivity	Human, Dog
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human TPMT (NP_000358) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	HRP
Storage Condition	Store at -20°C as received.
Predicted Protein Size	28.2 kDa
Gene Name	thiopurine S-methyltransferase
Database Link	NP_000358 Entrez Gene 403536 DogEntrez Gene 7172 Human UniProt ID P51580
Background	This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
Synonyms	OTTHUMP00000016076; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; thiopurine S-methyltransferase
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Drug metabolism - other enzymes

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