VASP Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1F3]

Specifications

Product Data
Clone Name	OTI1F3
Applications	IHC, WB
Recommend Dilution	WB 1:200~500, IHC 1:150
Reactivity	Human, Dog, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human VASP (NP_003361) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Gene Name	vasodilator stimulated phosphoprotein
Database Link	NP_003361 Entrez Gene 22323 MouseEntrez Gene 361517 RatEntrez Gene 403936 DogEntrez Gene 7408 Human UniProt ID P50552
Background	Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq]
Synonyms	vasodilator-stimulated phosphoprotein
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Fc gamma R-mediated phagocytosis, Focal adhesion, Leukocyte transendothelial migration

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