JAB1 (COPS5) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2B12]

Specifications

Product Data
Clone Name	OTI2B12
Applications	IF, IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150, IF 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human COPS5(NP_006828) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	37.4 kDa
Gene Name	COP9 signalosome subunit 5
Database Link	NP_006828 Entrez Gene 26754 MouseEntrez Gene 312916 RatEntrez Gene 10987 Human UniProt ID Q92905
Background	The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq]
Synonyms	CSN5; JAB1; MOV-34; SGN5
Reference Data
Protein Families	Druggable Genome, Protease, Transcription Factors

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