ATIC Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1D2]

Specifications

Product Data
Clone Name	OTI1D2
Applications	FC, WB
Recommend Dilution	WB 1:500~2000, FLOW 1:100
Reactivity	Human, Dog, Rat, Monkey, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human ATIC(NP_004035) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	64.4 kDa
Gene Name	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Database Link	NP_004035 Entrez Gene 81643 RatEntrez Gene 108147 MouseEntrez Gene 488513 DogEntrez Gene 694819 MonkeyEntrez Gene 471 Human UniProt ID P31939
Background	This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq]
Synonyms	AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH
Reference Data
Protein Families	Stem cell - Pluripotency
Protein Pathways	Metabolic pathways, One carbon pool by folate, Purine metabolism

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