BAX Rabbit Polyclonal Antibody
CNY 5,302.00
Cited in 3 publications. |
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 3,080.00
Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommend Dilution | WB 1:20000, IHC 1:150,ELISA 1:100-1:2000 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | DNA immunization. This antibody is specific for the N Terminus Region of the target protein. |
Formulation | 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0 |
Concentration | 0.8mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | BCL2 associated X, apoptosis regulator |
Database Link | |
Background | Bcl2 family is a key regulator of apoptosis that functions to either inhibit or promote cell death. Over-expression of members such as Bcl2 and BclxL inhibit the apoptotic process. The Bcl2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with Bcl2 resulting in the enhancement of the anti-apoptotic effect of Bcl2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial membranes, inducing mitochondrial damage and cell death in a caspase-independent manner. Bad plays a critical role in the Bax-mediated apoptosis pathway by dimerizing with BclxL, causing the displacment of Bax. The displacement of Bax allows apoptosis to proceed. BclxS, a shorter version of BclxL (lacking amino acids 126-188), apparently utilizes a different pathway than Bax to induce cell death. Some research suggests that BclxS uses a novel mechanism for regulating caspase or it may use an alternate cell death effector pathway. |
Synonyms | BCL2L4 |
Note | This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Huntington's disease, Neurotrophin signaling pathway, p53 signaling pathway, Pathways in cancer, Prion diseases |
Citations (3)
The use of this Antibodies has been cited in the following citations: |
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Impact of NF-κB pathway on the apoptosis-inflammation-autophagy crosstalk in human degenerative nucleus pulposus cells
,Yi, W;Wen, Y;Tan, F;Liu, X;Lan, H;Ye, H;Liu, B;,
Aging (Albany NY) 2019
,PubMed ID 31518335
[BAX]
|
An ellagic acid isolated from Clerodendrum viscosum leaves ameliorates iron-overload induced hepatotoxicity in Swiss albino mice through inhibition of oxidative stress and the apoptotic pathway
,Shendge, AK;Basu, T;Panja, S;Chaudhuri, D;Mandal, N;,
Biomed. Pharmacother.
,PubMed ID 29990833
[BAX]
|
Sundew plant, a potential source of anti-inflammatory agents, selectively induces G2/M arrest and apoptosis in MCF-7 cells through upregulation of p53 and Bax/Bcl-2 ratio
,Ghate, NB;Das, A;Chaudhuri, D;Panja, S;,
Cell Death Discovery
[Bax]
|
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