Papillary renal cell carcinoma (PRCC) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	WB 1:5000~20000, IHC 1:150,ELISA 1:100-1:2000
Reactivity	Human, Monkey, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	DNA immunization. This antibody is specific for the N Terminus Region of the target protein.
Formulation	20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Concentration	1.14mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	proline rich mitotic checkpoint control factor
Database Link	NP_955448 Entrez Gene 94315 MouseEntrez Gene 718660 MonkeyEntrez Gene 5546 Human UniProt ID Q92733
Background	In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect.
Synonyms	MGC4723; MGC17178; OTTHUMP00000038719; papillary renal cell carcinoma (translocation-associated); papillary renal cell carcinoma translocation-associated gene product; proline-rich protein PRCC; RCCP1; TPRC
Note	This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
Reference Data
Protein Families	Druggable Genome

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