RPA34 (RPA2) Rabbit Monoclonal Antibody [Clone ID: OTIR2G2]

CAT#: TA591019

Rabbit monoclonal anti-RFA2 antibody for SISCAPA, clone OTIR2G2



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CNY 4,390.00


货期*
4周

规格
    • 100 ul

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Specifications

Product Data
Clone Name OTIR2G2
Applications SISCAPA
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Immunogen Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human RPA2 (NP_002937). The exact sequence is proprietary.
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration Lot dependent; please refer to CoA along with shipment
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 32 kDa
Gene Name replication protein A2
Background This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]
Synonyms REPA2; RP-A p32; RP-A p34; RPA32
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways DNA replication, Homologous recombination, Mismatch repair, Nucleotide excision repair
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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