ATRX Rabbit Monoclonal Antibody [Clone ID: OTIR8G1]

Specifications

Product Data
Clone Name	OTIR8G1
Applications	IHC
Recommend Dilution	IHC 1:200
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to the N-terminus of human ATRX (NP_000480) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1.00mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws.
Predicted Protein Size	282.4 kDa
Gene Name	ATRX chromatin remodeler
Database Link	NP_000480 Entrez Gene 546 Human UniProt ID P46100
Background	The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Synonyms	JMS; MRX52; RAD54; RAD54L; XH2; XNP; ZNF-HX
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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